Publications

PTG-100

Model Based Predictions of the PTG-100 Pharmacodynamic Responses in Ulcerative Colitis Patients, Mattheakis, L., Fosser, C., Saralaya, R., Horsch, K., Rao, N., Bai, L., Zhao, L., Annamalai, T., Liu, D., 12th Congress of ECCO, February 17, 2017, Barcelona, Spain, View poster

Safety, Pharmacokinetics and Pharmacodynamics of the Novel Oral Peptide Therapeutic PTG-100 (α4β7 Integrin Antagonist) in Normal Healthy Volunteers, Shames, R., Tozzi, L., Mattheakis, L., Annamalai, T., Bhandari, A., and Liu, D., 24th United European Gastroenterology Week, October 15-19, 2016, Vienna, Austria, View poster

Pharmacokinetics and Pharmacodynamics Following Oral Administration Of PTG-100, a Peptide Antagonist of Integrin α4β7, Annamalai, T., Mattheakis, L., Bhandari, A., Liu, D., Zemede, G., Hadley, S., Zhao, L., Rao, N., 24th United European Gastroenterology Week, October 15-19, 2016, Vienna, Austria, View poster

Establishing the Human Equivalent Dose for PTG-100, an Oral Peptide Antagonist of Integrin α4β7, Mattheakis, L., Zemede, G., Bai, L., Tran, V., Celino, H., Frederick, B., Zhao, L., Dogra, M., Tovera, J., Shah, S., Rao, N., Hadley, S., Bhandari, A., Annamalai, T., Patel, D., Liu, D., Digestive Disease Week, May 21-24, 2016, San Diego, United States, View poster

PTG-100, an Oral Peptide Antagonist of Integrin α4β7 that Alters Trafficking of Gut Homing T Cells in Preclinical Animal Models, Mattheakis, L., Bhandari, A., Bai, L., Zemede, G., Tran, V., Celino, H., Frederick, B., Zhao, L., Dogra, M., Lister, H., Tovera, J., Shah, S., Annamalai, T., Patel , D., Liu, D., 2015 Advances in IBD – Crohn’s & Colitis Foundation’s Clinical & Research Conference, December 2015, View poster

Preclinical Characterization of PTG-100, an Oral α4β7 Integrin Peptide Antagonist for Treatment of Ulcerative Colitis, Mattheakis, L., Bhandari, A., Bai, L., Zemede, G., Tran, V., Spencer, N., Celino, H., Frederick, B., Dias, J., Zhao, L., Annamalai, T., Patel, D., Liu, D., ICMI 2015 July 14-18, 2015, Berlin, Germany, View poster

Integrin α4β7: Discovery of Gut-Restrictive Oral Peptide Antagonists that are Active in Murine Models of Inflammatory Bowel Disease, Mattheakis, L., Bhandari, A., Bai, L., Zemede, G., Tran, V., Spencer, N., Celino, H., Frederick, B., Xu, C., Dias, J., Annamalai, T., Habtezion, A., Patel, D., Liu, D., 2014 Advances in IBD – Crohn’s & Colitis Foundation’s Clinical & Research Conference, December 2014, View poster

PTG-200

The Biomarker Profile of PTG-200, an Oral Peptide Antagonist of IL-23 Receptor, Tracks with Efficacy in Preclinical Model of IBD, Cheng, X., Taranath, R., Mattheakis, L., Bhandari, A., Liu, D., 12th Congress of ECCO, February 17, 2017, Barcelona, Spain, View poster

The Biomarker Profile of PTG-200, an Oral Peptide Antagonist of IL-23 Receptor, Correlates with Efficacy in Preclinical Models of IBD, Cheng, X., Taranath, R., Zhao, L., Yuan, L., Shah, S., Foulke, M., Annamalai, T., Mattheakis, L., Bhandari, A., Patel, D., Liu, D., 2016 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation of America’s Clinical & Research Conference, December 9, 2016, Orlando, FL, View poster

Discovery of Novel Oral Peptide Antagonists of IL-23 Receptor that are Efficacious in Rat Model of IBD, Bhandari, A., Cheng, X., Bourne, G., Frederick, B., Zhang, J., McMahon, J., Celino, H., Zemede, G., Tran, V., Tovera, J., Dogra, M., Bai, L., Chen, L., Shaw, S., Annamalai, T., Mattheakis, L., Patel, D., Liu, D., 2015 Advances in IBD – Crohn’s & Colitis Foundation’s Clinical & Research Conference, December 2015, View poster

Discovery and Characterization of Novel Oral Peptide Antagonists of Human IL-23 Receptor that are Efficacious in a Rat Model of IBD, Cheng, X., Bhandari, A., Bourne, G., Frederick, B., Zhang, J., McMahon, J., Scott, S., Celino, H., Zemede, G., Spencer, N., Tran, V., Dogra, M., Dias, J., Bai, L., Annamalai, T., Smythe, M., Mattheakis, L., Patel, D., Liu, D., ICMI 2015 July 14-18, 2015, Berlin, Germany, View poster

PTG-300

Hepcidin Mimetic PTG-300 for Treatment of Ineffective Erythropoiesis and Chronic Anemia in Hemoglobinopathy Disease, Gregory Bourne, Li Zhao, Ashok Bhandari, Brian Frederick, Jaimee McMahon, Vinh Tran, Jenny Zhang, Adam Stephenson, Roopa Taranath, James Tovera, Thamil Annamalai, Larry Mattheakis, Dinesh Patel, Mark Smythe, David Liu, 23rd Congress of EHA, June 16, 2018, Stockholm, Sweden. View presentation

Hepcidin Mimetic PTG-300 Induces Dose-Related and Sustained Reductions in Serum Iron and Transferrin Saturation in Healthy Subjects, Andrew Nicholls, Jason Lickliter, Lucio Tozzi, David Liu, Richard Shames, 23rd Congress of EHA, June 16, 2018, Stockholm, Sweden. View presenatation

Hepcidin Mimetic PTG-300 for Treatment of Ineffective Erythropoiesis and Iron Overload, Gregory Bourne, Li Zhao, Ashok Bhandari, Brian Frederick, Jaimee McMahon, Vinh Tran, Jenny Zhang, Adam Stephenson, James Tovera, Lu Bai, Thamil Annamalai, Dinesh Patel, Mark Smythe, David Liu, Seventh Congress of the International Bioiron Society, May 7-11, 2017, Los Angeles, CA.

Hepcidin Mimetic PTG-300 for Treatment of Ineffective Erythropoiesis and Iron Overload Diseases, Greg Bourne, Li Zhao, Ashok Bhandari, Brian Frederick, Jaimee McMahon, Jenny Zhang, Adam Stephenson, Thamil Annamalai, Larry Mattheakis, Dinesh Patel, Mark Smythe, David Liu, 6th Modern Solid Phase Peptide Synthesis & Its Applications Symposium 2017, October 14, 2017, Fraser Island, Qld Australia.

Technology Platform

Orally Delivered Peptides for Treatment of Inflammatory Bowel Disease, Smythe, M. L, In: Samuel Chackalamannil, David P Rotella and Simon E Ward, (eds.), (2017), Comprehensive Medicinal Chemistry III vol. 6, pp. 157–170. Oxford: Elsevier. http://dx.doi.org/10.1016/B978-0-12-409547-2.12417-5

Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23, Barkan, D.T., Cheng,X-L., Celino, H., Tran, T.T., Bhandari, A., Craik, C.S., Sali, A., and Smythe, M.L., BMC Bioinformatics, (2016), 17, 481. https://doi.org/10.1186/s12859-016-1350-9

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo, Ranganath, S., Bhandari, A., Avitahl-Curtis, N., McMahon, J., Wachtel, D., Zhang J., Leitheiser C., Bernier, S.G., Liu, G., Tran, T.T., Celino, H., Tobin J., Jung, J., Zhao, H., Gle, K.E., Graul, C., Griffin, A., Schairer, W.C., Higgins, C., Reza, T.L., Mowe, E., Rivers, S., Scott, S., Monreal, A., Shea, C., Bourne, G., Coons, C., Smith, A., Tang, K., Mandyam, R.A., Masferer, J., Liu, D., Patel, D.V., Fretzen, A., Murphy, C.A., Milne, G.T., Smythe, M.L., Carlson, K.E., PLOS ONE (2015), 10(11), 1-19. (journals.plos.org/plosone/article?id=10.1371/journal.pone.0141330)

Conformational searching using a population-based incremental learning algorithm, Long, S.M., Tran, T.T., Adams, P., Darwen, P., Smythe, M.L., Journal of Computational Chemistry (2011) 32:1541-1549

Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions, Tran, T.T., Kulis, C., Long, S.M., Bryant, D., Adams, P., Smythe, M.L., Journal Computer Aided Molecular Design (2010) Vol 24, 917-934

Library of biphenyl privileged substructures using a safety-catch linker approach, Severinsen, R., Bourne, G.T., Tran, T.T., Ankersen, M., Begtrup, M., Smythe, M.L., Journal of Combinatorial Chemistry (2008) Vol 10, Issue 4, 557-566

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification, Horton, D.A., Bourne, G.T., Coughlan, J., Kaiser, S.M., Jacobs, C,M., Jones, A., Ruhmann, A., Turner, J.Y., Smythe, M.L., Organic & Biomolecular Chemistry (2008), Vol 6, Issue 8, 1386-1395

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